Studies on the effect of doxorubicin on MDA, NO2, NO3, Se-GSH peroxidase and SOD levels in albino rat tissues

Doxorubicin, a highly effective anticancer drug, produces cardiotoxicity, which limits its therapeutic potential. The mechanism of this cardiotoxicity has remained elusive. The use of this drug, however,continues to be limited by its dose-related and time interval toxicity. Reactive oxygen species are hypothesized to be a major factor in the toxicity of doxorubicin. The aim of this work was to investigate theeffect of doxorubicin on dose-related and time interval in rat. The study utilized adult albino rats (120 ± 5 g). They were divided into 8 groups of 7 animals each and were kept under standard laboratory conditions.They had free access to commercial pellet diet and water. The room temperature was maintained at 20 ± 5°C. The study measured rat tissue MDA, NO2, NO3, Se-GSH peroxidase and SOD under Dox stress, and the results indicate that MDA and NO generated in Dox treated samples cause neuro, myo, hepato and renal toxicity. Since SOD and Peroxidase are scavenging molecules, increase in their levels in Dox treated samples may be one of mechanism to overcome Dox caused oxidative stress in Dox treated albino rat

Analysis of the Different Medicinal Leaf with Fractal Dimension

Fractal analysis has been applied to describe various aspects connected with the complexity of plant morphology. In this work we determined the fractal dimension of leaves from various species of Peepal leaf, Castrol oil leaf, papaya leaf in order to characterize the structure/architecture of these leaves. The present study deals with the analysis of leaf shapes in terms of fractal geometry with medicinal leaves using the techniques of Image Processing. In this work we determined the fractal dimension of different leaves. The results are very informative

Rule Based Syntax Analyser for Telugu Poems

Natural language processing concerns about interpretation of language between human and machine such a way that machine can understand human language and communicate with a human so that human can understand. Challenging topics in this field is processing the Indian languages . The objective is to reduce human effort and time taken to perform tasks , improve the throughput and quality of a service. Chandhassu is a basic information to know whether a given poem is syntactically correct or not .Some poems are meaning full even though they doesn’t follow Chandhassu but those are not good when listening and reading .Nowadays so many peoples are writing poetry but those poems are not popular as much as ancient poets due to the lack of knowledge about Chandhassu and vyakaranamu. Proposed system is help full to check whether a given poem is syntactically correct or not. This system can be developed based on predefined rules for each type of Chandhassu .In Sanskrit Chandhassu types are called vruthas, some vruthas are adapted to write telugu poetry, Vruthas based on number of letters. In telugu Chandhassu types are called jaathulu and upajaathulu . these are dependent on number of ganalu. And also it checks whether poem follows yathi and prasa properties . Poetry can be useful to represent large amount of information in a small and structured format such a way that it can be easy to remember. Main applications of Chandasu is to write a poems, songs, prabhandas (collection of poems), dwipada (poems that follow a typical pattern), Sataka (collection of 100 poems) etc. By using poetry we can able to effectively represent sthayi bhavalu (symptoms) . It is helpful to represent science of Chandhassu ,vyakarana ,alnkara ,sahithyamu . Poetry is also used to represent dictionaries , medicine ,math’s , testing of vasthu ,pearls ,authentication purpose in data transition

Anti-Tumor Activity Of Four Ayurvedic Herbs In Dalton Lymphoma Ascites Bearing Mice And Their Short-Term In Vitro Cytotoxicity On DLA- Cell-Line

The anti-tumor activity and chemopreventive potential of four Ayurvedic herbs viz. Curcuma longa L., Ocimum sanctum L., Tinospora cordifolia (Wild) Miers ex Hook.f & Thomas and Zizyphus mauritiana Lam. were evaluated using Dalton Lymphoma ascites (DLA) tumor model in Swiss Albino mice. The outcome was assessed using survival time, peritoneal ascitic fluid (Tumor volume) and hematological indices as parameters. Animals were divided into five groups (n = 6) viz. one DLA control and four Herb + DLA treated groups. All the four herb + DLA groups were pre-treated with respective herbs for 7 days and hematological indices were measured for entire five groups. On day-8 animals were inoculated with 1x106 DLA cells i.p., and Herb + DLA groups were continued with oral herbal treatment for 21-days. Hematological parameters and tumor volume were assessed to find the effects of herbs. Short term in vitro cytotoxicity was determined by Trypan Blue exclusion method and LDH leakage assay using different concentrations of herbal extracts and 5-FU as a positive control and IC50 for each herbal extract and 5-FU were determined. Oral administration of crude herb increased the survival time and decreased the peritoneal ascitic fluid content significantly. Hb, RBCs and total WBC which were altered by DLA inoculation were restored significantly by all the herbs except O. sanctum. All the four herbs showed in vitro cytotoxic activity against DLA cell-line. Moreover inter group comparison of all the four herbs for anti-tumor activity showed efficacy in the following order- T. cordifolia > Z. mauritiana ≥ C. longa > O. sanctum respectively. Keywords: Curcuma longa; Ocimum sanctum; Tinospora cordifolia; Zizyphus mauritiana; DLA cell line; Cytotoxicity; Anti-tumor activityAfrican Journal of Trad, Comp and Alternative Medicine Vol. 5 (4) 2008: pp. 409-41

FPGA Implementation of Low Power Serial to High Speed Data Networks

FPGA based solutions become more common in embedded systems these days. These systems need to communicate with external world. Considering high-speed and popularity of Ethernet communication, developing a reliable real-time Ethernet component inside FPGA is of special value. To that end, we present a new solution for FPGA Gigabit Ethernet communications with timing analysis. The solution deals with "Gigabit Media-Independent Interface" in its physical layer. Network protocol is implemented from physical to transport layer which is UDP. In this Project using LAN connection various data will be captured by FPGA and will be sent on a serial line. Read the data from UART Receive and transform the data in it. On FPGA logic is implemented to read data from serial port. Write data in to memory location and transmitted data out put The FPGA module takes data from serial port and sends to PC in Ethernet form. In PC application will be developed to read data from Ethernet

Smart Wall Painting System

The objective of this paper is to outline a smart wall painting system for little and medium scale operations. These days robots are broadly utilized as a part of relatively every application like medicinal application, amusement, military, production lines vehicle businesses, and so on. However, the utilization of robot is as yet not generally utilized as a part of constructional work. Robots are fundamentally design to build speed and maximize accuracy of construction field work. The basic point of the paper is to design, develop and actualize Remote Operated Wall Painting Machine which helps for accomplishing painting hardware requiring little to no effort because of which the sketch work can be effectively done proficiently and in particular at extremely ostensible cost. The painting machine keeps away from coordinate contact of chemicals which can be harmful to the human painters, for example, eye, skin and respiratory system issues.. Besides that the idea of painting method that requires rehashed work time and hand rising make it physical torment, and exertion devouring. Moreover, it would offer the chance to decrease or take out human introduction to troublesome and dangerous worked system conditions, which would take care of a large portion of the issues associated with security when numerous activities happen in the meantime. This machine is is easy to operate and no need of labour required to operate effectively. At the point when development specialists and robots are appropriately coordinated in building tasks,the entire development process can be better overseen and savings in human work and timing are acquired as an outcome. wall painting is a redundant, debilitating and risky process which makes it a perfect case for automation. Painting had been mechanized in car industry however not yet for the development business. There is a strong requirement for a portable robot that can move to paint walls of buildings. In this paper, the conceptual plan of a an autonomous wall painting robot is portrayed comprising of an arm that sweeps the dividers vertically and is fitted on a versatile robot base to give the lateral feed movement to cover the painting area. The design objective is to fulfill the criteria of straight forwardness, low weight, ease and quick painting time. Ultrasonic sensors are fitted on the arm and the portable base to alter as far as possible and move in the room territory. A control system is intended to direct the arm movement and plan the versatile base movement

UML Modeling for Tea / Coffee Machine

Unified Modeling language (UML) is one of the important modeling languages used for the visual representation of the research problem. In the present paper, UML model is designed for the Tea / Coffee Machine which is used for the purpose of the public in the hotels or restaurants2019;. The class and use case diagrams are designe

Analysis of the Shape and Fractal Dimension of Medicinal Leaves by using Image Processing Techniques

Fractal analysis has been applied to describe various aspects connected with the complexity of plant morphology. In this work we have determined the fractal dimension of leaves. Some plants are considered as important source of nutrition and as a result, these plants are recommended for their therapeutic values. The common characteristic of such fractal objects is that their length depends on the length scale used to measure it, and the fractal dimension tells us the precise nature of this dependence. We estimated Fractal Dimension of different kinds of leaves by looking at their inner structure until to the cellular nucleus

Analysis of the Leaf Fractal Dimension

The present study deals with the analysis of leaf shapes in terms of fractal geometry with medicinal plant like Hibiscus Leaf, by using the techniques of Image Processing. Fractal analysis has been applied to describe various aspects connected with the complexity of plant morphology. In this work we determined the fractal dimension of leaves for four methods like Prewitt , Sobel , Roberts , Canny . We summarize the different methods that have been developed for estimating the fractal dimension of medicinal leaves. The results are very informative

Emergency Medical Care and Podiatry

Exam paper for first semester (Department of Applied Physics and Engineering Mathematics, B. Tech